Breast, Ovarian, Brain, Pancreatic, Colon and Other Cancer Innovations: From Prevention To Treatment and Cure

DISCLAIMER: NOTHING HEREIN SHOULD BE CONSTRUED AS MEDICAL ADVICE. ONLY A LICENSED PHYSICIAN CAN GIVE YOU ADVICE AND YOU SHOULD CONSULT WITH HIM OR HER. THIS PAPER IS FOR INFORMATIONAL PURPOSES ONLY.

By David William Jedell Updated November 1, 2024

Breastfeeding Lowers Your Breast & Ovarian Cancer Risk

You probably know that breastfeeding can give your baby a healthy start. But that’s not the only health benefit. It also can lower your breast cancer risk. Most women who breastfeed experience hormonal changes during lactation that delay their menstrual periods. This reduces a woman’s lifetime exposure to hormones like estrogen, which can promote breast cancer cell growth. Researchers found that for every 12 months a woman breastfed, her risk of breast cancer decreased by 4.3%. The study compared mothers who breastfed to those who didn’t. It also found the 12-month time period could be with either one child or as the total for several children. Further, women who breastfed for more than 13 months were 63% less likely to develop ovarian cancer than women who breastfed for less than seven months. And, women who breastfed multiple children for over 31 months could reduce their ovarian cancer risk by up to 91% compared to women who breastfed for under 10 months.[1]

Changes in Mammary Duct Cells

(As a sidenote, in 2017, researchers showed that pregnancy coincided with significant reductions in gray matter, and in 2022, a follow-up study among 28 volunteers found that pregnancy hormones changed the way the brain's networks are wired. https://www.sciencealert.com/profound-brain-changes-of-pregnancy-revealed-in-scientific-first)

Breast cancer researchers have mapped early genetic alterations in normal-looking cells at various distances from primary tumors to show how changes along the lining of mammary ducts can lead to disease.[2]

What is in Breast Milk

Researchers believe that a reaction takes place with breast milk when it hits the gut. It produces a protein called alpha-lactalbumin, which targets cancer cells. The breast milk compound targets cancer cells alone, offering an alternative to chemotherapy and radiotherapy treatments, which can damage both healthy and cancerous cells in the body.[3] In addition, during pregnancy and breastfeeding, you shed breast tissue. This shedding can help remove cells with potential DNA damage, thus helping to reduce your chances of developing breast cancer.[1]

Immunotherapy

An oncolytic virus called Maraba boosted the immune system. When it was used alongside a checkpoint inhibitor it cured between 60 and 90 per cent. When you infect a cancer cell with a virus, it raises a big red flag, which helps the immune system recognize and attack the cancer. Using a checkpoint inhibitor after the virus releases all the alarms and the immune system sends in the full army against the cancer.[4]

A First Abortion Increases Risk of Breast Cancer

Abortion before the first live birth stops the processes transforming the breast during the first pregnancy, which increases the risk of breast cancer. Progestogens stimulate considerable growth of undifferentiated cells in the breast during the first pregnancy, which, if pregnancy continues, results in the budding and branching of the network of milk ducts. This period of rapid growth during the first trimester is when these breast cells are most vulnerable to carcinogens. Interruption of pregnancy during this period prevents these breast cells from becoming differentiated during the second and third trimesters. Worldwide, one finds high breast cancer rates correlated with high induced abortion rates.[5]

Hormone replacement therapy can triple the risk of breast cancer

“We found that current use of combined HRT increases the risk of breast cancer by up to threefold, depending on how long HRT has been used.[6]

What Does a Breast Cancer Lump Feel Like?

In general, cancerous lumps tend to be more irregular in shape. They may also feel firm or solid, and might be fixed to the tissue in the breast. They are also often painless. However, in a small percentage of women, a painful breast lump turns out to be cancer. Cysts, which are fluid-filled lumps, are common in the breast and are benign. They form when fluid builds up inside breast glands, and tend to be smooth or round. Fibroadenomas, which are benign tumors made up of glandular and connective breast tissue, are usually smooth and firm or rubbery to the touch. Both of these conditions tend to affect younger women; fibroadenomas are most common in women in their 20s and 30s, and cysts are most common in women under 40.

Despite these common descriptions, it is impossible to tell by touch whether a lump is cancer.

The key point is that a woman should seek medical attention for any concerning lumps in her breasts.[7]

Suicide Molecules Possibly Kill any Cancer Cell

RNA assassin molecules called DISE, for Death Induced by Survival gene Elimination, were delivered via nanoparticles to mice bearing human ovarian cancer. In the treated mice, the treatment strongly reduced the tumor growth with no toxicity to the mice. Importantly, the tumors did not develop resistance to this form of cancer treatment.[8]

Other Promising Detection and Treatments

Limiting complication rates in implant-based breast reconstruction https://www.nzma.org.nz/journal/read-the-journal/all-issues/2010-2019/2018/vol-131-no-1470-23-february-2018/7493

Cancer breakthrough that allows doctors to transplant disease-fighting immune cells from strangers into patients save millions https://www.dailymail.co.uk/health/article-6532227/Future-cancer-incredibly-bright-scientists-transplant-immune-cells-patients.html

Dog sniffs out owner's ovarian cancer https://www.jsonline.com/story/news/columnists/jim-stingl/2018/11/30/womans-dog-detects-her-ovarian-cancer-three-times/2154700002/

Promising Results With Pembrolizumab/Niraparib in Platinum-Sensitive Ovarian Cancer https://www.targetedonc.com/news/expert-highlights-promising-results-with-pembrolizumabniraparib-in-platinumsensitive-ovarian-cancer

BRCA Mutations: Cancer Risk and Genetic Testing https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet

Ribociclib Granted Breakthrough Therapy Designation by FDA for HR+/HER2- Premenopausal Breast Cancer http://www.targetedonc.com/news/ribociclib-granted-breakthrough-therapy-designation-by-fda-for-hrher2-premenopausal-breast-cancer

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer https://www.nature.com/articles/s41591-018-0040-8

Ribociclib Granted Breakthrough Therapy Designation by FDA for HR+/HER2- Premenopausal Breast Cancer http://www.targetedonc.com/news/ribociclib-granted-breakthrough-therapy-designation-by-fda-for-hrher2-premenopausal-breast-cancer

Induced Vitamin B2 Deficiency in Cancer Therapy http://www.aging-us.com/article/101351/text

Wiping out 95% of test cancer cells in 24 hours - trials may start early 2018 https://www.dailystar.co.uk/news/latest-news/662276/cancer-cure-therapy-lift-biosciences-treatment-alex-blyth

Diagnostic for serum miRNA detection of ovarian cancer https://elifesciences.org/articles/28932

p53 has important implications for development of resistance in cancer therapy https://www.biorxiv.org/content/early/2017/10/16/204057

Cancer Fought By Designer Viruses http://www.business-standard.com/article/news-ians/designer-viruses-may-help-fight-cancer-117052601396_1.html

Promise of Olaparib/Durvalumab Combo in BRCA+ Breast Cancer http://www.targetedonc.com/news/expert-discusses-promise-of-olaparibdurvalumab-combo-in-brca-breast-cancer

Immunotherapy and a virus may kill the deadliest forms of breast & brain cancer http://www.dailymail.co.uk/health/article-5232165/Could-combination-cure-breast-cancer.html?ito=social-twitter_mailonline

Breast cancer: changes in normal-looking mammary duct cells leading to disease http://www.uhn.ca/corporate/News/PressReleases/Pages/Breast_cancer_researchers_track_changes_in_normal-looking_mammary_duct_cells_leading_to_disease.aspx?utm_content=buffera77fa&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

Blood "Biopsy" Shows Promise in Detecting Cancers https://directorsblog.nih.gov/2018/01/30/new-liquid-biopsy-shows-early-promise-in-detecting-cancer/

Breast cancer genetics revealed: 72 new mutations discovered in global study http://edition.cnn.com/2017/10/23/health/72-new-breast-cancer-mutations-study/

Researchers Forecast Cancer Research and Treatment Advances in 2018 http://blog.aacr.org/experts-forecast-cancer-research-and-treatment-advances-in-2018/?utm_source=social&utm_medium=twitter&utm_campaign=blog

Positron emission tomography triggers titanocene & free radicals kill cancer cells https://source.wustl.edu/2018/01/light-triggered-nanoparticles-show-promise-metastatic-cancer/

Enzalutamide efficacy vs. androgen receptor (AR)-positive triple-negative breast cancer http://www.onclive.com/web-exclusives/enzalutamide-shows-early-promise-in-arpositive-tnbc#sthash.ROc2jZ2J.uxfs

Family Cancer History Worksheet https://www.knowbrca.org/downloads/FCHWorksheet.pdf

Promising Cancer ‘Vaccine’ Eliminates 97% of Tumors http://stm.sciencemag.org/content/10/426/eaan4488.full

Recent Breast Cancer Treatment Advances http://www.onclive.com/web-exclusives/blackwell-sheds-light-on-recent-advances-in-her2-breast-cancer?platform=hootsuite

Triple-negative breast cancer study of novel therapeutic vaccine http://www.targetedonc.com/news/offtheshelf-vaccine-investigated-in-phase-ii-study-of-tnbc-for-recurrence-prevention

Mastectomy Versus Lumpectomy: 3 Questions to Ask Your Doctor https://www.hopkinsmedicine.org/health/healthy-woman/conditions/mastectomy-versus-lumpectomy-3-questions-to-ask-your-doctor

Prostheses

This study confirms that breast reconstruction using the patient's own tissue is safer than tissue expander/implant reconstruction in women facing radiation therapy after mastectomy. https://prma-enhance.com/breast-reconstruction-blog/breast-reconstruction-tissue-safer-than-implants-when-radiation-planned/

Silicone breast implants https://abcnews.go.com/Health/study-shows-link-breast-implants-rare-conditions-fda/story?id=57823483

Affordable Prostheses for Breast Cancer Survivors https://www.health24.com/Lifestyle/Woman/Your-body/finally-affordable-prostheses-for-breast-cancer-survivors-20180413

DIEP Flap Breast Reconstruction https://prma-enhance.com/breast-reconstruction/diep-flap/

Risk of recurrence and death in patients with breast cancer after delayed deep inferior epigastric perforator flap reconstruction https://onlinelibrary.wiley.com/doi/full/10.1002/bjs.10866

CAR T cell therapy is an innovative new approach that involves isolating a patient's immune cells, engineering them to become “super killer cells” and then re-infusing them into the patient to fight their cancer. While CAR T cell therapy has shown promise for brain cancer treatment, finding the right proteins to target on brain cancer cells has been a major hurdle. The WEHI-led study has revealed a protein called EphA3, found on the surface of high-grade glioma cells, could be a key target for CAR T cell therapy. https://www.wehi.edu.au/news/two-in-one-breakthrough-cutting-edge-immunotherapy/#:~:text=CAR%20T%20cell%20therapy%20is,patient%20to%20fight%20their%20cancer.

Can a New Drug Candidate Cure Pancreatic Cancer? Scientists have designed a molecule that disarms a cancer-causing mutation found in several cancers, including lung, breast and colon. UC San Francisco researchers have designed a candidate drug that could help make pancreatic cancer, which is almost always fatal, a treatable, perhaps even curable, condition. The new drug candidate permanently modifies a wily cancer-causing mutation, called K-Ras G12D, that is responsible for nearly half of all pancreatic cancer cases and appears in some forms of lung, breast and colon cancer. https://www.ucsf.edu/news/2024/03/427231/can-new-drug-candidate-cure-pancreatic-cancer

References

[1] Breastfeeding Lowers Your Breast Cancer Risk https://www.mdanderson.org/publications/focused-on-health/october-2014/breastfeeding-breast-cancer-prevention.html

[2] Breast cancer: changes in normal-looking mammary duct cells leading to disease http://www.uhn.ca/corporate/News/PressReleases/Pages/Breast_cancer_researchers_track_changes_in_normal-looking_mammary_duct_cells_leading_to_disease.aspx?

utm_content=buffera77fa&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

[3] Cancer: Breast Milk Produces Protein Alpha-Lactalbumin that Kills Cancerous Tumor Cells https://www.yahoo.com/beauty/breast-milk-latest-cancer-treatment-161252298.html

[4] Immunotherapy and a virus may kill the deadliest forms of breast & brain cancer

http://www.dailymail.co.uk/health/article-5232165/Could-combination-cure-breast-cancer.html?ito=social-twitter_mailonline

[5] Does abortion increase the risk of breast cancer? https://www.ncbi.nlm.nih.gov/pubmed/8006548

[6] HRT triples the risk of breast cancer, biggest ever study shows https://www.telegraph.co.uk/science/2016/08/22/hrt-triples-the-risk-of-breast-cancer-longest-ever-study-shows/

[7] What Does a Breast Cancer Lump Feel Like? http://blog.dana-farber.org/insight/2015/10/what-does-a-breast-cancer-lump-feel-like/

[8] Suicide molecules kill any cancer cell https://www.eurekalert.org/pub_releases/2017-10/nu-smk101917.php

Copyright © 2024 by David William Jedell Email: d.w.jedell@gmail.com